Navigation: Home Welcome to DDI-CPI!
[Sign In or Instant Entry]
Username: Register
Password: Forgot password?

No registration or login is required! Just hit the "Instant entry" Button!
Procedures and samples

Sample interactions indicated by our server

RSS feeds: Target updates, Library drug updates



Drugs are commonly co-prescribed and unexpected drug-drug interactions (DDIs) may occur and lead to adverse reactions, or even the termination or withdrawal of market drugs. Those DDIs are an obstacle for new discovery and applications of drug-drug combinations. As DDIs may be caused by unexpected drug-protein interactions, we can predict these interactions by studying and mining their profiles of Chemical-Protein Interactome (CPI).

What does DDI-CPI provide for you?

This server has a collection of 2000+ FDA approved drug molecules as library drugs, and 600+ ligand-bindable human proteins including both pharmacokinetic (PK) and pharmacodynamic (PD) targets. When you submit a molecule, the server will suggest putative targets that tend to interact with it, and will also give the predictions and estimated probabilities of DDIs between your molecule and our library drugs via mining their CPI profiles. By analyzing putative PK/PD proteins involved in the predictions, you may decipher potential mechanisms of DDIs mediated by unexpected drug-human protein interactions.

Sister servers

Visit a list of sister servers extending the same methodology of the chemical-protein interactome for drug development and discovery.