Identifying novel indications for old drug (drug repositioning) is an efficient way of enhancing drug safety and lowering R & D costs. Adverse drug reaction (ADR) is one of the leading causes of death among hospitalized patients. As both new indication and ADRs are caused by unexpected drug-protein interactions, it is reasonable to predict these interactions based on mining the Chemical-Protein Interactome (CPI).

What does DRAR-CPI™ provide for you?

This server has a representative collection of drug molecules and targetable human proteins built up from our work in drug repositioning and ADR. When you submit a molecule, the server will suggest candidate off-targets that tend to interact with it, and will also give the positive or negative association score between your molecule and our library drugs based on their interaction profiles of the CPI. Since our library drugs have the comprehensive annotation of the indications and ADRs, you can thus predict the indications or ADRs based on the association scores of your molecule across our library molecules.

The sister server extending the same methodology of the chemical-protein interactome