Chemical-Protein Interactome (rosiglitazone)

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Drug Namerosiglitazone
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Interactome of your molecule across the targetable proteins (download)

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NoPDB IDClassTarget nameFunctionDocking ScoreVisualization
1 2BZGPKThiopurine S-methyltransferaseCatalyzes the S-methylation of thiopurine drugs such as6-mercaptopurine.-10.5result
2 1FCYPDRetinoic acid receptor gammaReceptor for retinoic acid. Retinoic acid receptors bindas heterodimers to their target response elements in response totheir ligands, all-trans or 9-cis retinoic acid, and regulate geneexpression in various biological processes. The RAR/RXRheterodimers bind to the retinoic acid response elements (RARE)composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In theabsence of ligand, acts mainly as an activator of gene expressiondue to weak binding to corepressors. Required for limb buddevelopment. In concert with RARA or RARB, required for skeletalgrowth, matrix homeostasis and growth plate function (Bysimilarity).-10.3result
3 2H11PKThiopurine S-methyltransferaseCatalyzes the S-methylation of thiopurine drugs such as6-mercaptopurine.-10.2result
4 2Z5YPKAmine oxidase [flavin-containing] ACatalyzes the oxidative deamination of biogenic andxenobiotic amines and has important functions in the metabolism ofneuroactive and vasoactive amines in the central nervous systemand peripheral tissues. MAOA preferentially oxidizes biogenicamines such as 5-hydroxytryptamine (5-HT), norepinephrine andepinephrine.-10.2result
5 3HIGPKAmiloride-sensitive amine oxidase [copper-containing]Catalyzes the degradation of compounds such asputrescine, histamine, spermine, and spermidine, substancesinvolved in allergic and immune responses, cell proliferation,tissue differentiation, tumor formation, and possibly apoptosis.Placental DAO is thought to play a role in the regulation of thefemale reproductive function.-10.2result
6 1XAPPDRetinoic acid receptor betaReceptor for retinoic acid. Retinoic acid receptors bindas heterodimers to their target response elements in response totheir ligands, all-trans or 9-cis retinoic acid, and regulate geneexpression in various biological processes. The RXR/RARheterodimers bind to the retinoic acid response elements (RARE)composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In theabsence or presence of hormone ligand, acts mainly as an activatorof gene expression due to weak binding to corepressors. In concertwith RARG, required for skeletal growth, matrix homeostasis andgrowth plate function.-10.1result
7 1LS6_2PKSulfotransferase 1A1Sulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) as sulfonate donor to catalyze the sulfateconjugation of catecholamines, phenolic drugs andneurotransmitters. Has also estrogen sulfotransferase activity.responsible for the sulfonation and activation of minoxidil. IsMediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participateas modulating factor of cancer risk.-10result
8 1Z28PKSulfotransferase 1A1Sulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) as sulfonate donor to catalyze the sulfateconjugation of catecholamines, phenolic drugs andneurotransmitters. Has also estrogen sulfotransferase activity.responsible for the sulfonation and activation of minoxidil. IsMediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participateas modulating factor of cancer risk.-10result
9 2BXRPKAmine oxidase [flavin-containing] ACatalyzes the oxidative deamination of biogenic andxenobiotic amines and has important functions in the metabolism ofneuroactive and vasoactive amines in the central nervous systemand peripheral tissues. MAOA preferentially oxidizes biogenicamines such as 5-hydroxytryptamine (5-HT), norepinephrine andepinephrine.-10result
10 2Z5XPKAmine oxidase [flavin-containing] ACatalyzes the oxidative deamination of biogenic andxenobiotic amines and has important functions in the metabolism ofneuroactive and vasoactive amines in the central nervous systemand peripheral tissues. MAOA preferentially oxidizes biogenicamines such as 5-hydroxytryptamine (5-HT), norepinephrine andepinephrine.-10result
11 2Z5X_2PKAmine oxidase [flavin-containing] ACatalyzes the oxidative deamination of biogenic andxenobiotic amines and has important functions in the metabolism ofneuroactive and vasoactive amines in the central nervous systemand peripheral tissues. MAOA preferentially oxidizes biogenicamines such as 5-hydroxytryptamine (5-HT), norepinephrine andepinephrine.-10result
12 2Z5Y_2PKAmine oxidase [flavin-containing] ACatalyzes the oxidative deamination of biogenic andxenobiotic amines and has important functions in the metabolism ofneuroactive and vasoactive amines in the central nervous systemand peripheral tissues. MAOA preferentially oxidizes biogenicamines such as 5-hydroxytryptamine (5-HT), norepinephrine andepinephrine.-10result
13 2UXXPDLysine-specific histone demethylase 1AHistone demethylase that demethylates both 'Lys-4'(H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as acoactivator or a corepressor, depending on the context. Acts byoxidizing the substrate by FAD to generate the corresponding iminethat is subsequently hydrolyzed. Acts as a corepressor bymediating demethylation of H3K4me, a specific tag for epigenetictranscriptional activation. Demethylates both mono- (H3K4me1) anddi-methylated (H3K4me2) H3K4me. May play a role in the repressionof neuronal genes. Alone, it is unable to demethylate H3K4me onnucleosomes and requires the presence of RCOR1/CoREST to achievesuch activity. Also acts as a coactivator of androgen receptor(ANDR)-dependent transcription, by being recruited to ANDR targetgenes and mediating demethylation of H3K9me, a specific tag forepigenetic transcriptional repression. The presence of PRKCB inANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that preventsdemethylation H3K4me, prevents H3K4me demethylase activity ofKDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 whichprevents interaction of p53/TP53 with TP53BP1 and repressesp53/TP53-mediated transcriptional activation. Demethylates andstabilizes the DNA methylase DNMT1. Required for gastrulationduring embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complexthat suppresses, via histone deacetylase (HDAC) recruitment, anumber of genes implicated in multilineage blood cell development.-10result
14 1S3EPKAmine oxidase [flavin-containing] BCatalyzes the oxidative deamination of biogenic andxenobiotic amines and has important functions in the metabolism ofneuroactive and vasoactive amines in the central nervous systemand peripheral tissues. MAOB preferentially degrades benzylamineand phenylethylamine.-9.9result
15 1Z29PKSulfotransferase 1A2Sulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) as sulfonate donor to catalyze the sulfateconjugation of catecholamines, phenolic drugs andneurotransmitters. Is also responsible for the sulfonation andactivation of minoxidil. Mediates the metabolic activation ofcarcinogenic N-hydroxyarylamines to DNA binding products and couldso participate as modulating factor of cancer risk.-9.9result
16 2WJUPKGlutathione S-transferase A2Conjugation of reduced glutathione to a wide number ofexogenous and endogenous hydrophobic electrophiles.-9.9result
17 2XFNPKAmine oxidase [flavin-containing] BCatalyzes the oxidative deamination of biogenic andxenobiotic amines and has important functions in the metabolism ofneuroactive and vasoactive amines in the central nervous systemand peripheral tissues. MAOB preferentially degrades benzylamineand phenylethylamine.-9.9result
18 3IPQPDOxysterols receptor LXR-alphaOrphan receptor. Interaction with RXR shifts RXR fromits role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through targetgenes defined by LXRES. LXRES are DR4-type response elementscharacterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in theregulation of cholesterol homeostasis, regulating cholesteroluptake through MYLIP-dependent ubiquitination of LDLR, VLDLR andLRP8 (By similarity).-9.9result
19 3KFCPDOxysterols receptor LXR-betaOrphan receptor. Binds preferentially to double-strandedoligonucleotide direct repeats having the consensus half-sitesequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulatescholesterol uptake through MYLIP-dependent ubiquitination of LDLR,VLDLR and LRP8 (By similarity).-9.9result
20 1EFHPKBile salt sulfotransferaseSulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) as sulfonate donor to catalyze the sulfonation ofsteroids and bile acids in the liver and adrenal glands.-9.8result

Total:611   Page: /31


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